Tyson Lee Griffin (born April 20, 1984 in Sacramento, California) is a professional mixed martial arts fighter from Albany, CA. Griffin currently fights as a Lightweight in the Ultimate Fighting Championship (UFC).

Tyson Griffin began his professional career in 2004 in the Gladitorial Combat promotion. In his third bout, he dropped to featherweight to earn a TKO victory over future World Extreme Cagefighting featherweight champion Urijah Faber, which stood as Faber's only defeat for over three years. Griffin went on to win all of his first six fights before facing Duane Ludwig at Strikeforce: Revenge. He won the bout by TKO in the first round, attracting the attention of major promotions. After considering offers from Pride Fighting Championship and the UFC, Griffin signed with the UFC so that he could continue to fight stateside. While cornering for David Terrel at UFC 59 in Las Vegas, Griffin had an opportunity to meet members of the Xtreme Couture camp for the first time.

Griffin made his UFC debut at UFC 63 against David Lee. He won the bout by rear naked choke in the first round, earning a Submission of the Night honors in the process. Griffin used the money to move to Las Vegas and joined the Xtreme Couture camp. Former teammate Nick Diaz criticized Griffin as a "gym jumper", but Griffin rejected the accusation. He began 2007 with a fight against Frank Edgar at UFC 67. The back-and-forth bout ended with Edgar trapped in a tight leglock, but judges unanimously scored the bout in his favor, handing Griffin his first professional loss. He rebounded with two decision victories over Clay Guida and Thiago Tavares at UFC 72 and UFC 76, respectively. All three of his bouts in 2007 earned Fight of the Night honors and were judged in the top 10 best of year.

In 2008, Griffin won a unanimous decision victories over Gleison Tibau at UFC 81 and Marcus Aurelio at UFC 86. He next faced Sean Sherk at UFC 90, in a fight with title contension implications. In another three-round war, Griffin lost by unanimous decision, but won his fourth career Fight of the Night.

Griffin's entrances to UFC matches are often marked by his use of Survivor's "Eye of the Tiger".